Coach Andy Robinson has made just one change from the side that lost to Italy for the visit of England, with Nick De Luca coming in for Simon Danielli.
Max Evans moves to the wing to replace Danielli, with De Luca forming a centre partnership with Graeme Morrison.
Scrum-half Chris Cusiter continues as captain having shaken off a virus and he is partnered by fly-half Dan Parks who wins his 50th cap as the home Side look for their first win in the 2010 tournament.
H Southwell (Stade Francais); S Lamont (Scarlets), N De Luca (Edinburgh), G Morrison (Glasgow), M Evans (Glasgow); D Parks (Glasgow), C Cusiter (Glasgow, captain); A Jacobsen (Edinburgh), R Ford (Edinburgh), E Murray (Northampton); J Hamilton (Edinburgh), A Kellock (Glasgow); K Brown (Glasgow), J Barclay (Glasgow), J Beattie (Glasgow).
Replacements: S Lawson (Gloucester), G Cross (Edinburgh), N Hines (Leinster), A MacDonald (Edinburgh), R Lawson (Gloucester), P Godman (Edinburgh), S Danielli (Ulster).
RBS SIX NATIONS: Scotland v England Murrayfield, Edinburgh Saturday 13 March Kick-off: 1700 GMT