Ospreys prop Paul James is the shock Wales selection to play in the problem tight-head position against New Zealand at the Millennium Stadium on Saturday, whilst James Hook plays at full-back another position affected by injury.
Regular full-back Lee Byrne and tight-head Adam Jones are injured and wing Mark Jones joined them on Sunday. So Leigh Halfpenny and Shane Williams are on the wings while coach Warren Gatland has opted for Andy Powell at blindside flanker.
Wales starting XV v New Zealand
James Hook (Ospreys); Leigh Halfpenny, Tom Shanklin, Jamie Roberts (all Cardiff Blues), Shane Williams (Ospreys); Stephen Jones (Scarlets), Gareth Cooper; Gethin Jenkins (both Blues), Matthew Rees (Scarlets), Paul James, Alun-Wyn Jones (both Ospreys), Luke Charteris (Newport Gwent Dragons), Andy Powell, Martyn Williams (both Blues), Ryan Jones (Ospreys, capt).
Replacements: Huw Bennett, Duncan Jones, Bradley Davies, Dafydd Jones, Martin Roberts, Jonathan Davies, Tom James.
Wales squad for autumn international series
Backs: Dan Biggar James Hook, Shane Williams (Ospreys); Gareth Cooper, Jamie Roberts, Tom Shanklin, Tom James, Leigh Halfpenny (Blues); Martin Roberts, Stephen Jones, Jonathan Davies, Mark Jones (Scarlets); Dwayne Peel (Sale).
Forwards: Paul James, Duncan Jones, Craig Mitchell, Huw Bennett, Alun Wyn Jones, Ryan Jones (capt), Jonathan Thomas (Ospreys); Gethin Jenkins, Bradley Davies, Andy Powell, Sam Warburton, Martyn Williams (Blues); Matthew Rees, Dafydd Jones (Scarlets); Luke Charteris, Dan Lydiate (Dragons).
WALES v NEW ZEALAND Millennium Stadium, Cardiff 7 November Kick-off: 1715 GMT TV: BBC TWO Wales